The difference between Freebase nicotine and Nicotine Salts lies in their chemical structure and how they affect the vaping experience. Freebase nicotine is the purest form of nicotine, with a higher pH level, which results in a harsher throat hit and is better suited for lower nicotine strengths and higher-wattage devices. On the other hand, Nicotine Salts are created by combining nicotine with other compounds, which lowers the pH and creates a smoother throat hit. This allows for higher nicotine concentrations without the harshness, making them ideal for those who want a more intense and satisfying experience, similar to that of disposable vapes.